I can confirm that my DC53427 won't boot with my USB3-hub (and three external USB3-HDDs) connected. Freezes/hangs in or before the Firmware/BIOS gets to boot.
Somehow I got it to boot without freezing/hanging on boot:
- Make sure my connected USB3-Hub doesn't get external power from a seperate powersupply
- Use a "thicker" USB3-Cable to connect my USB3-Hub to my NUC (for making sure that the voltage drop between the NUC and my USB3-Hub is as low as possible)
- Disable all boot options except booting from the internal MSATA SSD
I also upgraded to the latest NUC Firmware/BIOS.